Theory, algorithms, and architectures for the formation, capture, processing, communication, analysis, and display of images, video, and multidimensional signals.
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Pathology foundation models (PFMs) have become central to computational pathology, aiming to offer general encoders for feature extraction from whole-slide images (WSIs). Despite strong benchmark performance, PFM robustness to real-world technical domain shifts, such as variability from whole-slide scanner devices, remains poorly understood. We systematically evaluated the robustness of 14 PFMs to scanner-induced variability, including state-of-the-art models, earlier self-supervised models, and a baseline trained on natural images. Using a multiscanner dataset of 384 breast cancer WSIs scanned on five devices, we isolated scanner effects independently from biological and laboratory confounders. Robustness is assessed via complementary unsupervised embedding analyses and a set of clinicopathological supervised prediction tasks. Our results demonstrate that current PFMs are not invariant to scanner-induced domain shifts. Most models encode pronounced scanner-specific variability in their embedding spaces. While AUC often remains stable, this masks a critical failure mode: scanner variability systematically alters the embedding space and impacts calibration of downstream model predictions, resulting in scanner-dependent bias that can impact reliability in clinical use cases. We further show that robustness is not a simple function of training data scale, model size, or model recency. None of the models provided reliable robustness against scanner-induced variability. While the models trained on the most diverse data, here represented by vision-language models, appear to have an advantage with respect to robustness, they underperformed on downstream supervised tasks. We conclude that development and evaluation of PFMs requires moving beyond accuracy-centric benchmarks toward explicit evaluation and optimisation of embedding stability and calibration under realistic acquisition variability.
Image deblurring is a challenging problem in imaging due to its highly ill-posed nature. Deep learning models have shown great success in tackling this problem but the quest for the best image quality has brought their computational complexity up, making them impractical on anything but powerful servers. Meanwhile, recent works have shown that mobile Lidars can provide complementary information in the form of depth maps that enhance deblurring quality. In this paper, we introduce a novel low-complexity neural network for depth-guided image deblurring. We show that the use of the wavelet transform to separate structural details and reduce spatial redundancy as well as efficient feature conditioning on the depth information are essential ingredients in developing a low-complexity model. Experimental results show competitive image quality against recent state-of-the-art models while reducing complexity by up to two orders of magnitude.
In this paper, we introduce a novel pipeline for predicting chemotherapy response in pediatric brain tumors that are not amenable to complete surgical resection, using pre-treatment magnetic resonance imaging combined with clinical information. Our method integrates a state-of-the-art pediatric brain tumor segmentation framework with radiomic feature extraction and clinical data through an ensemble of a Swin UNETR encoder and XGBoost classifier. The segmentation model delineates four tumor subregions enhancing tumor, non-enhancing tumor, cystic component and edema which are used to extract imaging biomarkers and generate predictive features. The Swin UNETR network classifies the response to treatment directly from these segmented MRI scans, while XGBoost predicts response using radiomics and clinical variables including legal sex, ethnicity, race, age at event (in days), molecular subtype, tumor locations, initial surgery status, metastatic status, metastasis location, chemotherapy type, protocol name and chemotherapy agents. The ensemble output provides a non-invasive estimate of chemotherapy response in this historically challenging population characterized by lower progression-free survival. Among compared approaches, our Swin-Ensemble achieved the best performance (precision for non effective cases=0.68, recall for non effective cases=0.85, precision for chemotherapy effective cases=0.64 and overall accuracy=0.69), outperforming Mamba-FeatureFuse, Swin UNETR encoder, and Swin-FeatureFuse models. Our findings suggest that this ensemble framework represents a promising step toward personalized therapy response prediction for pediatric low-grade glioma patients in need of chemotherapy treatment who are not suitable for complete surgical resection, a population with significantly lower progression free survival and for whom chemotherapy remains the primary treatment option.
Deep learning has achieved significant advancements in medical image segmentation. Currently, obtaining accurate segmentation outcomes is critically reliant on large-scale datasets with high-quality annotations. However, noisy annotations are frequently encountered owing to the complex morphological structures of organs in medical images and variations among different annotators, which can substantially limit the efficacy of segmentation models. Motivated by the fact that medical imaging annotator can correct labeling errors during segmentation based on prior knowledge, we propose an end-to-end Staged Voxel-Level Deep Reinforcement Learning (SVL-DRL) framework for robust medical image segmentation under noisy annotations. This framework employs a dynamic iterative update strategy to automatically mitigate the impact of erroneous labels without requiring manual intervention. The key advancements of SVL-DRL over existing works include: i) formulating noisy annotations as a voxel-dependent problem and addressing it through a novel staged reinforcement learning framework which guarantees robust model convergence; ii) incorporating a voxel-level asynchronous advantage actor-critic (vA3C) module that conceptualizes each voxel as an autonomous agent, which allows each agent to dynamically refine its own state representation during training, thereby directly mitigating the influence of erroneous labels; iii) designing a novel action space for the agents, along with a composite reward function that strategically combines the Dice value and a spatial continuity metric to significantly boost segmentation accuracy while maintain semantic integrity. Experiments on three public medical image datasets demonstrates State-of-The-Art (SoTA) performance under various experimental settings, with an average improvement of over 3\% in both Dice and IoU scores.
Synthetic Aperture Radar (SAR) imaging results are highly sensitive to observation geometries and the geometric parameters of targets. However, existing generative methods primarily operate within the image domain, neglecting explicit geometric information. This limitation often leads to unsatisfactory generation quality and the inability to precisely control critical parameters such as azimuth angles. To address these challenges, we propose GeoDiff-SAR, a geometric prior guided diffusion model for high-fidelity SAR image generation. Specifically, GeoDiff-SAR first efficiently simulates the geometric structures and scattering relationships inherent in real SAR imaging by calculating SAR point clouds at specific azimuths, which serves as a robust physical guidance. Secondly, to effectively fuse multi-modal information, we employ a feature fusion gating network based on Feature-wise Linear Modulation (FiLM) to dynamically regulate the weight distribution of 3D physical information, image control parameters, and textual description parameters. Thirdly, we utilize the Low-Rank Adaptation (LoRA) architecture to perform lightweight fine-tuning on the advanced Stable Diffusion 3.5 (SD3.5) model, enabling it to rapidly adapt to the distribution characteristics of the SAR domain. To validate the effectiveness of GeoDiff-SAR, extensive comparative experiments were conducted on real-world SAR datasets. The results demonstrate that data generated by GeoDiff-SAR exhibits high fidelity and effectively enhances the accuracy of downstream classification tasks. In particular, it significantly improves recognition performance across different azimuth angles, thereby underscoring the superiority of physics-guided generation.
Image restoration has traditionally required training specialized models on thousands of paired examples per degradation type. We challenge this paradigm by demonstrating that powerful pre-trained text-conditioned image editing models can be efficiently adapted for multiple restoration tasks through parameter-efficient fine-tuning with remarkably few examples. Our approach fine-tunes LoRA adapters on FLUX.1 Kontext, a state-of-the-art 12B parameter flow matching model for image-to-image translation, using only 16-128 paired images per task, guided by simple text prompts that specify the restoration operation. Unlike existing methods that train specialized restoration networks from scratch with thousands of samples, we leverage the rich visual priors already encoded in large-scale pre-trained editing models, dramatically reducing data requirements while maintaining high perceptual quality. A single unified LoRA adapter, conditioned on task-specific text prompts, effectively handles multiple degradations including denoising, deraining, and dehazing. Through comprehensive ablation studies, we analyze: (i) the impact of training set size on restoration quality, (ii) trade-offs between task-specific versus unified multi-task adapters, (iii) the role of text encoder fine-tuning, and (iv) zero-shot baseline performance. While our method prioritizes perceptual quality over pixel-perfect reconstruction metrics like PSNR/SSIM, our results demonstrate that pre-trained image editing models, when properly adapted, offer a compelling and data-efficient alternative to traditional image restoration approaches, opening new avenues for few-shot, prompt-guided image enhancement. The code to reproduce our results are available at: https://github.com/makinyilmaz/Edit2Restore
Generative joint source-channel coding (GJSCC) has emerged as a new Deep JSCC paradigm for achieving high-fidelity and robust image transmission under extreme wireless channel conditions, such as ultra-low bandwidth and low signal-to-noise ratio. Recent studies commonly adopt diffusion models as generative decoders, but they frequently produce visually realistic results with limited semantic consistency. This limitation stems from a fundamental mismatch between reconstruction-oriented JSCC encoders and generative decoders, as the former lack explicit semantic discriminability and fail to provide reliable conditional cues. In this paper, we propose DiT-JSCC, a novel GJSCC backbone that can jointly learn a semantics-prioritized representation encoder and a diffusion transformer (DiT) based generative decoder, our open-source project aims to promote the future research in GJSCC. Specifically, we design a semantics-detail dual-branch encoder that aligns naturally with a coarse-to-fine conditional DiT decoder, prioritizing semantic consistency under extreme channel conditions. Moreover, a training-free adaptive bandwidth allocation strategy inspired by Kolmogorov complexity is introduced to further improve the transmission efficiency, thereby indeed redefining the notion of information value in the era of generative decoding. Extensive experiments demonstrate that DiT-JSCC consistently outperforms existing JSCC methods in both semantic consistency and visual quality, particularly in extreme regimes.
Accurate and automated lesion segmentation in Positron Emission Tomography / Computed Tomography (PET/CT) imaging is essential for cancer diagnosis and therapy planning. This paper presents a Swin Transformer UNet 3D (SwinUNet3D) framework for lesion segmentation in Fluorodeoxyglucose Positron Emission Tomography / Computed Tomography (FDG-PET/CT) scans. By combining shifted window self-attention with U-Net style skip connections, the model captures both global context and fine anatomical detail. We evaluate SwinUNet3D on the AutoPET III FDG dataset and compare it against a baseline 3D U-Net. Results show that SwinUNet3D achieves a Dice score of 0.88 and IoU of 0.78, surpassing 3D U-Net (Dice 0.48, IoU 0.32) while also delivering faster inference times. Qualitative analysis demonstrates improved detection of small and irregular lesions, reduced false positives, and more accurate PET/CT fusion. While the framework is currently limited to FDG scans and trained under modest GPU resources, it establishes a strong foundation for future multi-tracer, multi-center evaluations and benchmarking against other transformer-based architectures. Overall, SwinUNet3D represents an efficient and robust approach to PET/CT lesion segmentation, advancing the integration of transformer-based models into oncology imaging workflows.
AV2 is the successor to the AV1 royalty-free video coding standard developed by the Alliance for Open Media (AOMedia). Its primary objective is to deliver substantial compression gains and subjective quality improvements while maintaining low-complexity encoder and decoder operations. This paper describes the transform, quantization and entropy coding design in AV2, including redesigned transform kernels and data-driven transforms, expanded transform partitioning, and a mode & coefficient dependent transform signaling. AV2 introduces several new coding tools including Intra/Inter Secondary Transforms (IST), Trellis Coded Quantization (TCQ), Adaptive Transform Coding (ATC), Probability Adaptation Rate Adjustment (PARA), Forward Skip Coding (FSC), Cross Chroma Component Transforms (CCTX), Parity Hiding (PH) tools and improved lossless coding. These advances enable AV2 to deliver the highest quality video experience for video applications at a significantly reduced bitrate.
Solving inverse problems in imaging requires models that support efficient inference, uncertainty quantification, and principled probabilistic reasoning. Energy-Based Models (EBMs), with their interpretable energy landscapes and compositional structure, are well-suited for this task but have historically suffered from high computational costs and training instability. To overcome the historical shortcomings of EBMs, we introduce a fast distillation strategy to transfer the strengths of pre-trained diffusion models into multi-scale EBMs. These distilled EBMs enable efficient sampling and preserve the interpretability and compositionality inherent to potential-based frameworks. Leveraging EBM compositionality, we propose Annealed Langevin Posterior Sampling (ALPS) algorithm for Maximum-A-Posteriori (MAP), Minimum Mean Square Error (MMSE), and uncertainty estimates for inverse problems in imaging. Unlike diffusion models that use complex guidance strategies for latent variables, we perform annealing on static posterior distributions that are well-defined and composable. Experiments on image inpainting and MRI reconstruction demonstrate that our method matches or surpasses diffusion-based baselines in both accuracy and efficiency, while also supporting MAP recovery. Overall, our framework offers a scalable and principled solution for inverse problems in imaging, with potential for practical deployment in scientific and clinical settings. ALPS code is available at the GitHub repository \href{https://github.com/JyoChand/ALPS}{ALPS}.
Accurate crop yield prediction relies on diverse data streams, including satellite, meteorological, soil, and topographic information. However, despite rapid advances in machine learning, existing approaches remain crop- or region-specific and require data engineering efforts. This limits scalability, reproducibility, and operational deployment. This study introduces UniCrop, a universal and reusable data pipeline designed to automate the acquisition, cleaning, harmonisation, and engineering of multi-source environmental data for crop yield prediction. For any given location, crop type, and temporal window, UniCrop automatically retrieves, harmonises, and engineers over 200 environmental variables (Sentinel-1/2, MODIS, ERA5-Land, NASA POWER, SoilGrids, and SRTM), reducing them to a compact, analysis-ready feature set utilising a structured feature reduction workflow with minimum redundancy maximum relevance (mRMR). To validate, UniCrop was applied to a rice yield dataset comprising 557 field observations. Using only the selected 15 features, four baseline machine learning models (LightGBM, Random Forest, Support Vector Regression, and Elastic Net) were trained. LightGBM achieved the best single-model performance (RMSE = 465.1 kg/ha, $R^2 = 0.6576$), while a constrained ensemble of all baselines further improved accuracy (RMSE = 463.2 kg/ha, $R^2 = 0.6604$). UniCrop contributes a scalable and transparent data-engineering framework that addresses the primary bottleneck in operational crop yield modelling: the preparation of consistent and harmonised multi-source data. By decoupling data specification from implementation and supporting any crop, region, and time frame through simple configuration updates, UniCrop provides a practical foundation for scalable agricultural analytics. The code and implementation documentation are shared in https://github.com/CoDIS-Lab/UniCrop.
Synthetic aperture radar (SAR) provides valuable information about the Earth's surface under all weather and illumination conditions. However, the inherent phenomenon of speckle and the presence of sidelobes around bright targets pose challenges for accurate interpretation of SAR imagery. Most existing SAR image restoration methods address despeckling and sidelobes reduction as separate tasks. In this paper, we propose a unified framework that jointly performs both tasks using neural networks (NNs) trained on a realistic SAR simulated dataset generated with MOCEM. Inference can then be performed on real SAR images, demonstrating effective simulation to real (Sim2Real) transferability. Additionally, we incorporate acquisition metadata as auxiliary input to the NNs, demonstrating improved restoration performance.
This paper introduces SENA (SEamlessly NAtural), a geometry-driven image stitching approach that prioritizes structural fidelity in challenging real-world scenes characterized by parallax and depth variation. Conventional image stitching relies on homographic alignment, but this rigid planar assumption often fails in dual-camera setups with significant scene depth, leading to distortions such as visible warps and spherical bulging. SENA addresses these fundamental limitations through three key contributions. First, we propose a hierarchical affine-based warping strategy, combining global affine initialization with local affine refinement and smooth free-form deformation. This design preserves local shape, parallelism, and aspect ratios, thereby avoiding the hallucinated structural distortions commonly introduced by homography-based models. Second, we introduce a geometry-driven adequate zone detection mechanism that identifies parallax-minimized regions directly from the disparity consistency of RANSAC-filtered feature correspondences, without relying on semantic segmentation. Third, building upon this adequate zone, we perform anchor-based seamline cutting and segmentation, enforcing a one-to-one geometric correspondence across image pairs by construction, which effectively eliminates ghosting, duplication, and smearing artifacts in the final panorama. Extensive experiments conducted on challenging datasets demonstrate that SENA achieves alignment accuracy comparable to leading homography-based methods, while significantly outperforming them in critical visual metrics such as shape preservation, texture integrity, and overall visual realism.
While one-step diffusion models have recently excelled in perceptual image compression, their application to video remains limited. Prior efforts typically rely on pretrained 2D autoencoders that generate per-frame latent representations independently, thereby neglecting temporal dependencies. We present YODA--Yet Another One-step Diffusion-based Video Compressor--which embeds multiscale features from temporal references for both latent generation and latent coding to better exploit spatial-temporal correlations for more compact representation, and employs a linear Diffusion Transformer (DiT) for efficient one-step denoising. YODA achieves state-of-the-art perceptual performance, consistently outperforming traditional and deep-learning baselines on LPIPS, DISTS, FID, and KID. Source code will be publicly available at https://github.com/NJUVISION/YODA.
Artificial intelligence models have shown strong potential in acute ischemic stroke imaging, particularly for lesion detection and segmentation using computed tomography and magnetic resonance imaging. However, most existing approaches operate as black box predictors, producing deterministic outputs without explicit uncertainty awareness or structured mechanisms to abstain under ambiguous conditions. This limitation raises serious safety and trust concerns in high risk emergency radiology settings. In this paper, we propose an explainable agentic AI framework for uncertainty aware and abstention enabled decision support in acute ischemic stroke imaging. The framework follows a modular agentic pipeline in which a perception agent performs lesion aware image analysis, an uncertainty estimation agent computes slice level predictive reliability, and a decision agent determines whether to issue a prediction or abstain based on predefined uncertainty thresholds. Unlike prior stroke imaging systems that primarily focus on improving segmentation or classification accuracy, the proposed framework explicitly prioritizes clinical safety, transparency, and clinician aligned decision behavior. Qualitative and case based analyses across representative stroke imaging scenarios demonstrate that uncertainty driven abstention naturally emerges in diagnostically ambiguous regions and low information slices. The framework further integrates visual explanation mechanisms to support both predictive and abstention decisions, addressing a key limitation of existing uncertainty aware medical imaging systems. Rather than introducing a new performance benchmark, this work presents agentic control, uncertainty awareness, and selective abstention as essential design principles for developing safe and trustworthy medical imaging AI systems.
Medical image segmentation faces critical challenges in semi-supervised learning scenarios due to severe annotation scarcity requiring expert radiological knowledge, significant inter-annotator variability across different viewpoints and expertise levels, and inadequate multi-scale feature integration for precise boundary delineation in complex anatomical structures. Existing semi-supervised methods demonstrate substantial performance degradation compared to fully supervised approaches, particularly in small target segmentation and boundary refinement tasks. To address these fundamental challenges, we propose SASNet (Scale-aware Adaptive Supervised Network), a dual-branch architecture that leverages both low-level and high-level feature representations through novel scale-aware adaptive reweight mechanisms. Our approach introduces three key methodological innovations, including the Scale-aware Adaptive Reweight strategy that dynamically weights pixel-wise predictions using temporal confidence accumulation, the View Variance Enhancement mechanism employing 3D Fourier domain transformations to simulate annotation variability, and segmentation-regression consistency learning through signed distance map algorithms for enhanced boundary precision. These innovations collectively address the core limitations of existing semi-supervised approaches by integrating spatial, temporal, and geometric consistency principles within a unified optimization framework. Comprehensive evaluation across LA, Pancreas-CT, and BraTS datasets demonstrates that SASNet achieves superior performance with limited labeled data, surpassing state-of-the-art semi-supervised methods while approaching fully supervised performance levels. The source code for SASNet is available at https://github.com/HUANGLIZI/SASNet.
Fetal ultrasound standard-plane classification underpins reliable prenatal biometry and anomaly screening, yet real-world deployment is limited by domain shift, image noise, and poor calibration of predicted probabilities. This paper presents a practical framework for uncertainty-calibrated explainable AI in fetal plane classification. We synthesize uncertainty estimation methods (Monte Carlo dropout, deep ensembles, evidential learning, and conformal prediction) with post-hoc and uncertainty-aware explanations (Grad-CAM variants, LIME-style local surrogates, and uncertainty-weighted multi-resolution activation maps), and we map these components to a clinician-facing workflow. Using FETAL_PLANES_DB as a reference benchmark, we define a reporting protocol that couples accuracy with calibration and selective prediction, including expected calibration error, Brier score, coverage-risk curves, and structured error analysis with explanations. We also discuss integration points for quality control and human-in-the-loop review, where uncertainty flags trigger re-acquisition or expert confirmation. The goal is a reproducible, clinically aligned blueprint for building fetal ultrasound classifiers whose confidence and explanations remain trustworthy under noisy acquisition conditions.
Medical image analysis faces two critical challenges: scarcity of labeled data and lack of model interpretability, both hindering clinical AI deployment. Few-shot learning (FSL) addresses data limitations but lacks transparency in predictions. Active learning (AL) methods optimize data acquisition but overlook interpretability of acquired samples. We propose a dual-framework solution: Expert-Guided Explainable Few-Shot Learning (EGxFSL) and Explainability-Guided AL (xGAL). EGxFSL integrates radiologist-defined regions-of-interest as spatial supervision via Grad-CAM-based Dice loss, jointly optimized with prototypical classification for interpretable few-shot learning. xGAL introduces iterative sample acquisition prioritizing both predictive uncertainty and attention misalignment, creating a closed-loop framework where explainability guides training and sample selection synergistically. On the BraTS (MRI), VinDr-CXR (chest X-ray), and SIIM-COVID-19 (chest X-ray) datasets, we achieve accuracies of 92\%, 76\%, and 62\%, respectively, consistently outperforming non-guided baselines across all datasets. Under severe data constraints, xGAL achieves 76\% accuracy with only 680 samples versus 57\% for random sampling. Grad-CAM visualizations demonstrate guided models focus on diagnostically relevant regions, with generalization validated on breast ultrasound confirming cross-modality applicability.
Melanoma is the most lethal subtype of skin cancer, and early and accurate detection of this disease can greatly improve patients' outcomes. Although machine learning models, especially convolutional neural networks (CNNs), have shown great potential in automating melanoma classification, their diagnostic reliability still suffers due to inconsistent focus on lesion areas. In this study, we analyze the relationship between lesion attention and diagnostic performance, involving masked images, bounding box detection, and transfer learning. We used multiple explainability and sensitivity analysis approaches to investigate how well models aligned their attention with lesion areas and how this alignment correlated with precision, recall, and F1-score. Results showed that models with a higher focus on lesion areas achieved better diagnostic performance, suggesting the potential of interpretable AI in medical diagnostics. This study provides a foundation for developing more accurate and trustworthy melanoma classification models in the future.
Semantic segmentation is crucial for medical image analysis, enabling precise disease diagnosis and treatment planning. However, many advanced models employ complex architectures, limiting their use in resource-constrained clinical settings. This paper proposes MFEnNet, an efficient medical image segmentation framework that incorporates MetaFormer in the encoding phase of the U-Net backbone. MetaFormer, an architectural abstraction of vision transformers, provides a versatile alternative to convolutional neural networks by transforming tokenized image patches into sequences for global context modeling. To mitigate the substantial computational cost associated with self-attention, the proposed framework replaces conventional transformer modules with pooling transformer blocks, thereby achieving effective global feature aggregation at reduced complexity. In addition, Swish activation is used to achieve smoother gradients and faster convergence, while spatial pyramid pooling is incorporated at the bottleneck to improve multi-scale feature extraction. Comprehensive experiments on different medical segmentation benchmarks demonstrate that the proposed MFEnNet approach attains competitive accuracy while significantly lowering computational cost compared to state-of-the-art models. The source code for this work is available at https://github.com/tranleanh/mfennet.
Susceptibility Map Weighted Imaging (SMWI) is an advanced magnetic resonance imaging technique used to detect nigral hyperintensity in Parkinsons disease. However, full resolution SMWI acquisition is limited by long scan times. Efficient reconstruction methods are therefore required to generate high quality SMWI from reduced k space data while preserving diagnostic relevance. In this work, we propose a complex valued Swin Transformer based network for super resolution reconstruction of multi echo MRI data. The proposed method reconstructs high quality SMWI images from low resolution k space inputs. Experimental results demonstrate that the method achieves a structural similarity index of 0.9116 and a mean squared error of 0.076 when reconstructing SMWI from 256 by 256 k space data, while maintaining critical diagnostic features. This approach enables high quality SMWI reconstruction from reduced k space sampling, leading to shorter scan times without compromising diagnostic detail. The proposed method has the potential to improve the clinical applicability of SMWI for Parkinsons disease and support faster and more efficient neuroimaging workflows.
Magnetic Resonance Imaging (MRI) plays a pivotal role in the early diagnosis and monitoring of Alzheimer's disease (AD). However, the subtle structural variations in brain MRI scans often pose challenges for conventional deep learning models to extract discriminative features effectively. In this work, we propose PseudoColorViT-Alz, a colormap-enhanced Vision Transformer framework designed to leverage pseudo-color representations of MRI images for improved Alzheimer's disease classification. By combining colormap transformations with the global feature learning capabilities of Vision Transformers, our method amplifies anatomical texture and contrast cues that are otherwise subdued in standard grayscale MRI scans. We evaluate PseudoColorViT-Alz on the OASIS-1 dataset using a four-class classification setup (non-demented, moderate dementia, mild dementia, and very mild dementia). Our model achieves a state-of-the-art accuracy of 99.79% with an AUC of 100%, surpassing the performance of recent 2024--2025 methods, including CNN-based and Siamese-network approaches, which reported accuracies ranging from 96.1% to 99.68%. These results demonstrate that pseudo-color augmentation combined with Vision Transformers can significantly enhance MRI-based Alzheimer's disease classification. PseudoColorViT-Alz offers a robust and interpretable framework that outperforms current methods, providing a promising tool to support clinical decision-making and early detection of Alzheimer's disease.
Prenatal ultrasound is the cornerstone for detecting congenital anomalies of the kidneys and urinary tract, but diagnosis is limited by operator dependence and suboptimal imaging conditions. We sought to assess the performance of a self-supervised ultrasound foundation model for automated fetal renal anomaly classification using a curated dataset of 969 two-dimensional ultrasound images. A pretrained Ultrasound Self-Supervised Foundation Model with Masked Autoencoding (USF-MAE) was fine-tuned for binary and multi-class classification of normal kidneys, urinary tract dilation, and multicystic dysplastic kidney. Models were compared with a DenseNet-169 convolutional baseline using cross-validation and an independent test set. USF-MAE consistently improved upon the baseline across all evaluation metrics in both binary and multi-class settings. USF-MAE achieved an improvement of about 1.87% (AUC) and 7.8% (F1-score) on the validation set, 2.32% (AUC) and 4.33% (F1-score) on the independent holdout test set. The largest gains were observed in the multi-class setting, where the improvement in AUC was 16.28% and 46.15% in F1-score. To facilitate model interpretability, Score-CAM visualizations were adapted for a transformer architecture and show that model predictions were informed by known, clinically relevant renal structures, including the renal pelvis in urinary tract dilation and cystic regions in multicystic dysplastic kidney. These results show that ultrasound-specific self-supervised learning can generate a useful representation as a foundation for downstream diagnostic tasks. The proposed framework offers a robust, interpretable approach to support the prenatal detection of renal anomalies and demonstrates the promise of foundation models in obstetric imaging.
Medical image registration drives quantitative analysis across organs, modalities, and patient populations. Recent deep learning methods often combine low-level "trend-driven" computational blocks from computer vision, such as large-kernel CNNs, Transformers, and state-space models, with high-level registration-specific designs like motion pyramids, correlation layers, and iterative refinement. Yet, their relative contributions remain unclear and entangled. This raises a central question: should future advances in registration focus on importing generic architectural trends or on refining domain-specific design principles? Through a modular framework spanning brain, lung, cardiac, and abdominal registration, we systematically disentangle the influence of these two paradigms. Our evaluation reveals that low-level "trend-driven" computational blocks offer only marginal or inconsistent gains, while high-level registration-specific designs consistently deliver more accurate, smoother, and more robust deformations. These domain priors significantly elevate the performance of a standard U-Net baseline, far more than variants incorporating "trend-driven" blocks, achieving an average relative improvement of $\sim3\%$. All models and experiments are released within a transparent, modular benchmark that enables plug-and-play comparison for new architectures and registration tasks (https://github.com/BailiangJ/rethink-reg). This dynamic and extensible platform establishes a common ground for reproducible and fair evaluation, inviting the community to isolate genuine methodological contributions from domain priors. Our findings advocate a shift in research emphasis: from following architectural trends to embracing domain-specific design principles as the true drivers of progress in learning-based medical image registration.
Many GPUs have incorporated hardware-accelerated video encoders, which allow video encoding tasks to be offloaded from the main CPU and provide higher power efficiency. Over the years, many new video codecs such as H.265/HEVC, VP9, and AV1 were added to the latest GPU boards. Recently, the rise of live video content such as VTuber, game live-streaming, and live event broadcasts, drives the demand for high-efficiency hardware encoders in the GPUs to tackle these real-time video encoding tasks, especially at higher resolutions such as 4K/8K UHD. In this paper, RD performance, encoding speed, as well as power consumption of hardware encoders in several generations of NVIDIA, Intel GPUs as well as Qualcomm Snapdragon Mobile SoCs were evaluated and compared to the software counterparts, including the latest H.266/VVC codec, using several metrics including PSNR, SSIM, and machine-learning based VMAF. The results show that modern GPU hardware encoders can match the RD performance of software encoders in real-time encoding scenarios, and while encoding speed increased in newer hardware, there is mostly negligible RD performance improvement between hardware generations. Finally, the bitrate required for each hardware encoder to match YouTube transcoding quality was also calculated.
The proposed study aimed to develop a deep learning model capable of detecting ventriculomegaly on prenatal ultrasound images. Ventriculomegaly is a prenatal condition characterized by dilated cerebral ventricles of the fetal brain and is important to diagnose early, as it can be associated with an increased risk for fetal aneuploidies and/or underlying genetic syndromes. An Ultrasound Self-Supervised Foundation Model with Masked Autoencoding (USF-MAE), recently developed by our group, was fine-tuned for a binary classification task to distinguish fetal brain ultrasound images as either normal or showing ventriculomegaly. The USF-MAE incorporates a Vision Transformer encoder pretrained on more than 370,000 ultrasound images from the OpenUS-46 corpus. For this study, the pretrained encoder was adapted and fine-tuned on a curated dataset of fetal brain ultrasound images to optimize its performance for ventriculomegaly detection. Model evaluation was conducted using 5-fold cross-validation and an independent test cohort, and performance was quantified using accuracy, precision, recall, specificity, F1-score, and area under the receiver operating characteristic curve (AUC). The proposed USF-MAE model reached an F1-score of 91.76% on the 5-fold cross-validation and 91.78% on the independent test set, with much higher scores than those obtained by the baseline models by 19.37% and 16.15% compared to VGG-19, 2.31% and 2.56% compared to ResNet-50, and 5.03% and 11.93% compared to ViT-B/16, respectively. The model also showed a high mean test precision of 94.47% and an accuracy of 97.24%. The Eigen-CAM (Eigen Class Activation Map) heatmaps showed that the model was focusing on the ventricle area for the diagnosis of ventriculomegaly, which has explainability and clinical plausibility.
Accurate fluence map prediction is essential in intensity-modulated radiation therapy (IMRT) to maximize tumor coverage while minimizing dose to healthy tissues. Conventional optimization is time-consuming and dependent on planner expertise. This study presents a deep learning framework that accelerates fluence map generation while maintaining clinical quality. An end-to-end 3D Swin-UNETR network was trained to predict nine-beam fluence maps directly from volumetric CT images and anatomical contours using 99 prostate IMRT cases (79 for training and 20 for testing). The transformer-based model employs hierarchical self-attention to capture both local anatomical structures and long-range spatial dependencies. Predicted fluence maps were imported into the Eclipse Treatment Planning System for dose recalculation, and model performance was evaluated using beam-wise fluence correlation, spatial gamma analysis, and dose-volume histogram (DVH) metrics. The proposed model achieved an average R^2 of 0.95 +/- 0.02, MAE of 0.035 +/- 0.008, and gamma passing rate of 85 +/- 10 percent (3 percent / 3 mm) on the test set, with no significant differences observed in DVH parameters between predicted and clinical plans. The Swin-UNETR framework enables fully automated, inverse-free fluence map prediction directly from anatomical inputs, enhancing spatial coherence, accuracy, and efficiency while offering a scalable and consistent solution for automated IMRT plan generation.
Algorithmic bias in medical imaging can perpetuate health disparities, yet its causes remain poorly understood in segmentation tasks. While fairness has been extensively studied in classification, segmentation remains underexplored despite its clinical importance. In breast cancer segmentation, models exhibit significant performance disparities against younger patients, commonly attributed to physiological differences in breast density. We audit the MAMA-MIA dataset, establishing a quantitative baseline of age-related bias in its automated labels, and reveal a critical Biased Ruler effect where systematically flawed labels for validation misrepresent a model's actual bias. However, whether this bias originates from lower-quality annotations (label bias) or from fundamentally more challenging image characteristics remains unclear. Through controlled experiments, we systematically refute hypotheses that the bias stems from label quality sensitivity or quantitative case difficulty imbalance. Balancing training data by difficulty fails to mitigate the disparity, revealing that younger patient cases are intrinsically harder to learn. We provide direct evidence that systemic bias is learned and amplified when training on biased, machine-generated labels, a critical finding for automated annotation pipelines. This work introduces a systematic framework for diagnosing algorithmic bias in medical segmentation and demonstrates that achieving fairness requires addressing qualitative distributional differences rather than merely balancing case counts.
Ultrasound imaging is one of the most widely used diagnostic modalities, offering real-time, radiation-free assessment across diverse clinical domains. However, interpretation of ultrasound images remains challenging due to high noise levels, operator dependence, and limited field of view, resulting in substantial inter-observer variability. Current Deep Learning approaches are hindered by the scarcity of large labeled datasets and the domain gap between general and sonographic images, which limits the transferability of models pretrained on non-medical data. To address these challenges, we introduce the Ultrasound Self-Supervised Foundation Model with Masked Autoencoding (USF-MAE), the first large-scale self-supervised MAE framework pretrained exclusively on ultrasound data. The model was pre-trained on 370,000 2D and 3D ultrasound images curated from 46 open-source datasets, collectively termed OpenUS-46, spanning over twenty anatomical regions. This curated dataset has been made publicly available to facilitate further research and reproducibility. Using a Vision Transformer encoder-decoder architecture, USF-MAE reconstructs masked image patches, enabling it to learn rich, modality-specific representations directly from unlabeled data. The pretrained encoder was fine-tuned on three public downstream classification benchmarks: BUS-BRA (breast cancer), MMOTU-2D (ovarian tumors), and GIST514-DB (gastrointestinal stromal tumors). Across all tasks, USF-MAE consistently outperformed conventional CNN and ViT baselines, achieving F1-scores of 81.6%, 79.6%, and 82.4%, respectively. Despite not using labels during pretraining, USF-MAE approached the performance of the supervised foundation model UltraSam on breast cancer classification and surpassed it on the other tasks, demonstrating strong cross-anatomical generalization.
Chromatin sensitive partial wave spectroscopic (csPWS) microscopy enables label free detection of nanoscale chromatin packing alterations that occur before visible cellular transformation. However, manual nuclear segmentation limits population scale analysis needed for biomarker discovery in early cancer detection. The lack of annotated csPWS imaging data prevents direct use of standard deep learning methods. We present CFU Net, a hierarchical segmentation architecture trained with a three stage curriculum on synthetic multimodal data. CFU Net achieves near perfect performance on held out synthetic test data that represent diverse spectroscopic imaging conditions without manual annotations (Dice 0.9879, IoU 0.9895). Our approach uses physics based rendering that incorporates empirically supported chromatin packing statistics, Mie scattering models, and modality specific noise, combined with a curriculum that progresses from adversarial RGB pretraining to spectroscopic fine tuning and histology validation. CFU Net integrates five architectural elements (ConvNeXt backbone, Feature Pyramid Network, UNet plus plus dense connections, dual attention, and deep supervision) that together improve Dice over a baseline UNet by 8.3 percent. We demonstrate deployment ready INT8 quantization with 74.9 percent compression and 0.15 second inference, giving a 240 times throughput gain over manual analysis. Applied to more than ten thousand automatically segmented nuclei from synthetic test data, the pipeline extracts chromatin biomarkers that distinguish normal from pre cancerous tissue with large effect sizes (Cohens d between 1.31 and 2.98), reaching 94 percent classification accuracy. This work provides a general framework for synthetic to real transfer learning in specialized microscopy and open resources for community validation on clinical specimens.
Tractography fiber clustering using diffusion MRI (dMRI) is a crucial method for white matter (WM) parcellation to enable analysis of brains structural connectivity in health and disease. Current fiber clustering strategies primarily use the fiber geometric characteristics (i.e., the spatial trajectories) to group similar fibers into clusters, while neglecting the functional and microstructural information of the fiber tracts. There is increasing evidence that neural activity in the WM can be measured using functional MRI (fMRI), providing potentially valuable multimodal information for fiber clustering to enhance its functional coherence. Furthermore, microstructural features such as fractional anisotropy (FA) can be computed from dMRI as additional information to ensure the anatomical coherence of the clusters. In this paper, we develop a novel deep learning fiber clustering framework, namely Deep Multi-view Fiber Clustering (DMVFC), which uses joint multi-modal dMRI and fMRI data to enable functionally consistent WM parcellation. DMVFC can effectively integrate the geometric and microstructural characteristics of the WM fibers with the fMRI BOLD signals along the fiber tracts. DMVFC includes two major components: (1) a multi-view pretraining module to compute embedding features from each source of information separately, including fiber geometry, microstructure measures, and functional signals, and (2) a collaborative fine-tuning module to simultaneously refine the differences of embeddings. In the experiments, we compare DMVFC with two state-of-the-art fiber clustering methods and demonstrate superior performance in achieving functionally meaningful and consistent WM parcellation results.
Developing embodied AI agents requires scalable training environments that balance content diversity with physics accuracy. World simulators provide such environments but face distinct limitations: video-based methods generate diverse content but lack real-time physics feedback for interactive learning, while physics-based engines provide accurate dynamics but face scalability limitations from costly manual asset creation. We present Seed3D 1.0, a foundation model that generates simulation-ready 3D assets from single images, addressing the scalability challenge while maintaining physics rigor. Unlike existing 3D generation models, our system produces assets with accurate geometry, well-aligned textures, and realistic physically-based materials. These assets can be directly integrated into physics engines with minimal configuration, enabling deployment in robotic manipulation and simulation training. Beyond individual objects, the system scales to complete scene generation through assembling objects into coherent environments. By enabling scalable simulation-ready content creation, Seed3D 1.0 provides a foundation for advancing physics-based world simulators. Seed3D 1.0 is now available on https://console.volcengine.com/ark/region:ark+cn-beijing/experience/vision?modelId=doubao-seed3d-1-0-250928&tab=Gen3D
Medical image segmentation serves as a critical component of precision medicine, enabling accurate localization and delineation of pathological regions, such as lesions. However, existing models empirically apply fixed thresholds (e.g., 0.5) to differentiate lesions from the background, offering no statistical guarantees on key metrics such as the false negative rate (FNR). This lack of principled risk control undermines their reliable deployment in high-stakes clinical applications, especially in challenging scenarios like 3D lesion segmentation (3D-LS). To address this issue, we propose a risk-constrained framework, termed Conformal Lesion Segmentation (CLS), that calibrates data-driven thresholds via conformalization to ensure the test-time FNR remains below a target tolerance $\varepsilon$ under desired risk levels. CLS begins by holding out a calibration set to analyze the threshold setting for each sample under the FNR tolerance, drawing on the idea of conformal prediction. We define an FNR-specific loss function and identify the critical threshold at which each calibration data point just satisfies the target tolerance. Given a user-specified risk level $α$, we then determine the approximate $1-α$ quantile of all the critical thresholds in the calibration set as the test-time confidence threshold. By conformalizing such critical thresholds, CLS generalizes the statistical regularities observed in the calibration set to new test data, providing rigorous FNR constraint while yielding more precise and reliable segmentations. We validate the statistical soundness and predictive performance of CLS on six 3D-LS datasets across five backbone models, and conclude with actionable insights for deploying risk-aware segmentation in clinical practice.
Algorithm unrolling methods have proven powerful for solving the regularized least squares problem in computational magnetic resonance imaging (MRI). These approaches unfold an iterative algorithm with a fixed number of iterations, typically alternating between a neural network-based proximal operator for regularization, a data fidelity operation and auxiliary updates with learnable parameters. While the connection to optimization methods dictate that the proximal operator network should be shared across unrolls, this can introduce artifacts or blurring. Heuristically, practitioners have shown that using distinct networks may be beneficial, but this significantly increases the number of learnable parameters, making it challenging to prevent overfitting. To address these shortcomings, by taking inspirations from proximal operators with varying thresholds in approximate message passing (AMP) and the success of time-embedding in diffusion models, we propose a time-embedded algorithm unrolling scheme for inverse problems. Specifically, we introduce a novel perspective on the iteration-dependent proximal operation in vector AMP (VAMP) and the subsequent Onsager correction in the context of algorithm unrolling, framing them as a time-embedded neural network. Similarly, the scalar weights in the data fidelity operation and its associated Onsager correction are cast as time-dependent learnable parameters. Our extensive experiments on the fastMRI dataset, spanning various acceleration rates and datasets, demonstrate that our method effectively reduces aliasing artifacts and mitigates noise amplification, achieving state-of-the-art performance. Furthermore, we show that our time-embedding strategy extends to existing algorithm unrolling approaches, enhancing reconstruction quality without increasing the computational complexity significantly.
As the popularity of video streaming entertainment continues to grow, understanding how users engage with the content and react to its changes becomes a critical success factor for every stakeholder. User engagement, i.e., the percentage of video the user watches before quitting, is central to customer loyalty, content personalization, ad relevance, and A/B testing. This paper presents DIGITWISE, a digital twin-based approach for modeling adaptive video streaming engagement. Traditional adaptive bitrate (ABR) algorithms assume that all users react similarly to video streaming artifacts and network issues, neglecting individual user sensitivities. DIGITWISE leverages the concept of a digital twin, a digital replica of a physical entity, to model user engagement based on past viewing sessions. The digital twin receives input about streaming events and utilizes supervised machine learning to predict user engagement for a given session. The system model consists of a data processing pipeline, machine learning models acting as digital twins, and a unified model to predict engagement. DIGITWISE employs the XGBoost model in both digital twins and unified models. The proposed architecture demonstrates the importance of personal user sensitivities, reducing user engagement prediction error by up to 5.8% compared to non-user-aware models. Furthermore, DIGITWISE can optimize content provisioning and delivery by identifying the features that maximize engagement, providing an average engagement increase of up to 8.6%.
Incomplete multi-view data, where certain views are entirely missing for some samples, poses significant challenges for traditional multi-view clustering methods. Existing deep incomplete multi-view clustering approaches often rely on static fusion strategies or two-stage pipelines, leading to suboptimal fusion results and error propagation issues. To address these limitations, this paper proposes a novel incomplete multi-view clustering framework based on Hierarchical Semantic Alignment and Cooperative Completion (HSACC). HSACC achieves robust cross-view fusion through a dual-level semantic space design. In the low-level semantic space, consistency alignment is ensured by maximizing mutual information across views. In the high-level semantic space, adaptive view weights are dynamically assigned based on the distributional affinity between individual views and an initial fused representation, followed by weighted fusion to generate a unified global representation. Additionally, HSACC implicitly recovers missing views by projecting aligned latent representations into high-dimensional semantic spaces and jointly optimizes reconstruction and clustering objectives, enabling cooperative learning of completion and clustering. Experimental results demonstrate that HSACC significantly outperforms state-of-the-art methods on five benchmark datasets. Ablation studies validate the effectiveness of the hierarchical alignment and dynamic weighting mechanisms, while parameter analysis confirms the model's robustness to hyperparameter variations.
Traumatic brain injuries present significant diagnostic challenges in emergency medicine, where the timely interpretation of medical images is crucial for patient outcomes. In this paper, we propose a novel AI-based approach for automatic radiology report generation tailored to cranial trauma cases. Our model integrates an AC-BiFPN with a Transformer architecture to capture and process complex medical imaging data such as CT and MRI scans. The AC-BiFPN extracts multi-scale features, enabling the detection of intricate anomalies like intracranial hemorrhages, while the Transformer generates coherent, contextually relevant diagnostic reports by modeling long-range dependencies. We evaluate the performance of our model on the RSNA Intracranial Hemorrhage Detection dataset, where it outperforms traditional CNN-based models in both diagnostic accuracy and report generation. This solution not only supports radiologists in high-pressure environments but also provides a powerful educational tool for trainee physicians, offering real-time feedback and enhancing their learning experience. Our findings demonstrate the potential of combining advanced feature extraction with transformer-based text generation to improve clinical decision-making in the diagnosis of traumatic brain injuries.
We introduce the Information-Estimation Metric (IEM), a novel form of distance function derived from an underlying continuous probability density over a domain of signals. The IEM is rooted in a fundamental relationship between information theory and estimation theory, which links the log-probability of a signal with the errors of an optimal denoiser, applied to noisy observations of the signal. In particular, the IEM between a pair of signals is obtained by comparing their denoising error vectors over a range of noise amplitudes. Geometrically, this amounts to comparing the score vector fields of the blurred density around the signals over a range of blur levels. We prove that the IEM is a valid global metric and derive a closed-form expression for its local second-order approximation, which yields a Riemannian metric. For Gaussian-distributed signals, the IEM coincides with the Mahalanobis distance. But for more complex distributions, it adapts, both locally and globally, to the geometry of the distribution. In practice, the IEM can be computed using a learned denoiser (analogous to generative diffusion models) and solving a one-dimensional integral. To demonstrate the value of our framework, we learn an IEM on the ImageNet database. Experiments show that this IEM is competitive with or outperforms state-of-the-art supervised image quality metrics in predicting human perceptual judgments.
Medical image registration is critical for clinical applications, and fair benchmarking of different methods is essential for monitoring ongoing progress in the field. To date, the Learn2Reg 2020-2023 challenges have released several complementary datasets and established metrics for evaluations. Building on this foundation, the 2024 edition expands the challenge's scope to cover a wider range of registration scenarios, particularly in terms of modality diversity and task complexity, by introducing three new tasks, including large-scale multi-modal registration and unsupervised inter-subject brain registration, as well as the first microscopy-focused benchmark within Learn2Reg. The new datasets also inspired new method developments, including invertibility constraints, pyramid features, keypoints alignment and instance optimisation. Visit Learn2Reg at https://learn2reg.grand-challenge.org.
Accelerated Cardiovascular Magnetic Resonance (CMR) image reconstruction remains a critical challenge due to the trade-off between scan time and image quality, particularly when generalizing across diverse acquisition settings. We propose GENRE-CMR, a generative adversarial network (GAN)-based architecture employing a residual deep unrolled reconstruction framework to enhance reconstruction fidelity and generalization. The architecture unrolls iterative optimization into a cascade of convolutional subnetworks, enriched with residual connections to enable progressive feature propagation from shallow to deeper stages. To further improve performance, we integrate two loss functions: (1) an Edge-Aware Region (EAR) loss, which guides the network to focus on structurally informative regions and helps prevent common reconstruction blurriness; and (2) a Statistical Distribution Alignment (SDA) loss, which regularizes the feature space across diverse data distributions via a symmetric KL divergence formulation. Extensive experiments confirm that GENRE-CMR surpasses state-of-the-art methods on training and unseen data, achieving 0.9552 SSIM and 38.90 dB PSNR on unseen distributions across various acceleration factors and sampling trajectories. Ablation studies confirm the contribution of each proposed component to reconstruction quality and generalization. Our framework presents a unified and robust solution for high-quality CMR reconstruction, paving the way for clinically adaptable deployment across heterogeneous acquisition protocols.