The significance of NNLO (3-loop) QCD contributions to the flavor non-singlet sector of F_2^ep and F_2^ed has been studied as compared to uncertainties (different factorization schemes, higher twist and QED contributions) of standard NLO (and LO) QCD analyses. The latter effects turn out to be comparable in size to the NNLO contributions. Therefore the minute NNLO effects are not observable with presently available data on non-singlet structure functions.