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Equal Marginal Power for Co-Primary Endpoints

Simon Bond

TL;DR

A method is provided to achieve equal marginal power by using the flexibility provided in multiple testing procedures to achieve equal marginal power by using the flexibility provided in multiple testing procedures.

Abstract

The choice of sample size in the context of co-primary endpoints for a randomised trial is discussed. Current guidance can leave endpoints with unequal marginal power. A method is provided to achieve equal marginal power by using the flexibility provided in multiple testing procedures. A comparison is made to several choices of rule to determine the sample size, in terms of the study design and its operating characteristics.

Equal Marginal Power for Co-Primary Endpoints

TL;DR

A method is provided to achieve equal marginal power by using the flexibility provided in multiple testing procedures to achieve equal marginal power by using the flexibility provided in multiple testing procedures.

Abstract

The choice of sample size in the context of co-primary endpoints for a randomised trial is discussed. Current guidance can leave endpoints with unequal marginal power. A method is provided to achieve equal marginal power by using the flexibility provided in multiple testing procedures. A comparison is made to several choices of rule to determine the sample size, in terms of the study design and its operating characteristics.
Paper Structure (9 sections, 3 equations, 3 figures, 1 table)

This paper contains 9 sections, 3 equations, 3 figures, 1 table.

Table of Contents

  1. Introduction
  2. Definitions and notation
  3. Novel Method
  4. Example
  5. Conjunctive and Disjunctive power
  6. Operating Characteristics
  7. Sample Size
  8. Power under alternative hypotheses
  9. Conclusions

Figures (3)

  • Figure 1: Graphical Representation of multiple testing across three endpoints
  • Figure 2: Comparing the sample sizes
  • Figure 3: Comparing the probability of each possible outcome from testing