We develop the Lefschetz fixed-point theory for noncompact manifolds of bounded geometry and uniformly continuous maps. Specifically, we define the uniform Lefschetz class of a uniformly continuous map of a uniform simply-connected noncompact complete Riemannian manifold of bounded geometry satisfying , and prove that if and only if is uniformly homotopic to a strongly fixed-point free (without fixed-points on and at infinity) uniformly continuous map. To achieve this, we introduce a new cohomology for metric spaces, called uniform bounded cohomology, which is a variant of bounded cohomology, and develop an obstruction theory formulated in terms of this cohomology.