We initiate a general quantitative study of sets of -points, which are special subsets of rational points, generalizing Campana points, Darmon points, and squarefree solutions of Diophantine equations. We propose an asymptotic formula for the number of -points of bounded height on rationally connected varieties, extending Manin's conjecture as well as its generalization to Campana points by Pieropan, Smeets, Tanimoto and Várilly-Alvarado. Finally, we show that the conjecture explains several previously established results in arithmetic statistics.