Developing Large Language Models for Clinical Research Using One Million Clinical Trials

Zifeng Wang; Jiacheng Lin; Qiao Jin; Junyi Gao; Jathurshan Pradeepkumar; Pengcheng Jiang; Zhiyong Lu; Jimeng Sun

Paper

Developing Large Language Models for Clinical Research Using One Million Clinical Trials

Abstract

Developing artificial intelligence (AI) for clinical research requires a comprehensive data foundation that supports model training and rigorous evaluation. Here, we introduce TrialPanorama, a large-scale structured resource that aggregates 1.6M clinical trial records from fifteen global registries and links them with biomedical ontologies and associated literature. To demonstrate its utility, we build a pipeline that constructs 152K training and testing samples for eight key clinical research tasks. Three tasks support systematic review workflows, including study search, study screening, and evidence summarization. Five tasks focus on trial design and optimization, including arm design, eligibility criteria design, endpoint selection, sample size estimation, and trial completion assessment and rationalization. Benchmarking cutting-edge large language models (LLMs) reveals that generic LLMs have limited capability in clinical reasoning. In contrast, an 8B LLM we developed on TrialPanorama using supervised finetuning and reinforcement learning wins over the 70B generic counterparts in all eight tasks, with a relative improvement of 73.7%, 67.6%, 38.4%, 37.8%, 26.5%, 20.7%, 20.0%, 18.1%, and 5.2%, respectively. We envision that TrialPanorama provides a solid foundation for future scaling of AI for clinical research.