Analysis of a two phase flow model of biofilm spread

TL;DR

This analysis relies on the construction of weak solutions for the steady transport equations under sign assumptions and the reformulation of the compressible Stokes problem as an elliptic system with enhanced regularity properties on the pressure.

Abstract

Free boundaries of biofilms advancing on surfaces evolve according to conservation laws coupled with systems of partial differential equations for velocities, pressures and chemicals affecting cell behavior. Thin film approximations lead to complicated quasi-stationary systems coupling stationary transport equations and compressible Stokes systems with convection-reaction-diffusion equations.We establish existence, uniqueness and stability of solutions of the different submodels involved and then obtain well posedness results for the full system. Our analysis relies on the construction of weak solutions for the steady transport equations under sign assumptions and the reformulation of the compressible Stokes problem as an elliptic system with enhanced regularity properties on the pressure. We need to consider velocity fields whose divergence and normal boundary components satisfy sign conditions, instead of vanishing as classical results require. Applications include the study of cells, biofilms and tissues, where one phase is a liquid solution, whereas the other one is assorted biomass.

Figures (1)

• Figure 1: Schematic visualization of a biofilm slice. (a) Biofilm occupying a finite region. The upper boundary joins the lower boundary at triple points forming angles. (b) Biofilm with precursor layers around the bulk of the film.